CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study led by University of Illinois Urbana-Champaign researchers suggests. The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now. 

Artificial intelligence is often employed in the field of cancer genomics, where bits of DNA sequencing data must be identified and further analyzed with statistical, evolutional, and probabilistic models. “Off-the-shelf” computing tools are useful for many cancer researchers, but Mohammed El-Kebir (IGOH), Cancer Center at Illinois (CCIL) scientist, is taking these AI applications a step further.

Treating breast tumors with two cancer drugs simultaneously may prevent endocrine resistance by attacking the disease along two separate gene pathways, scientists at the University of Illinois found in a new study.

The two drugs used in the study, selinexor and 4-OHT, caused the cancer cells to die and tumors to regress for prolonged periods, said food science and human nutrition professor Zeynep Madak-Erdogan (ONC-PM), the principal investigator on the study.