Geddes, E. J., Gugger, M., Garcia, A., Garcia Chavez, M., Lee, M. R., Perlmutter, S. J., Bieniossek, C., Guasch, L., & Hergenrother, P. (2023). Porin-independent accumulation in Pseudomonas enables antibiotic discovery. Nature, 624(7990), 145-153. https://doi.org/10.1038/s41586-023-06760-8
Boudreau, M. W., Tonogai, E. J., Schane, C. P., Xi, M. X., Fischer, J. H., Vijayakumar, J., Ji, Y., Tarasow, T. M., Fan, T. M., Hergenrother, P. J., & Dudek, A. Z. (2023). The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma. Melanoma research, 33(6), 514-524. https://doi.org/10.1097/CMR.0000000000000927
Yu, L., Xu, L., Chu, H., Peng, J., Sacharidou, A., Hsieh, H. H., Weinstock, A., Khan, S., Ma, L., Durán, J. G. B., McDonald, J., Nelson, E. R., Park, S., McDonnell, D. P., Moore, K. J., Huang, L. J. S., Fisher, E. A., Mineo, C., Huang, L., & Shaul, P. W. (2023). Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature communications, 14(1), Article 4101. https://doi.org/10.1038/s41467-023-39586-z
Maji, A., Soutar, C. P., Zhang, J., Lewandowska, A., Uno, B. E., Yan, S., Shelke, Y., Murhade, G., Nimerovsky, E., Borcik, C. G., Arango, A. S., Lange, J. D., Marin-Toledo, J. P., Lyu, Y., Bailey, K. L., Roady, P. J., Holler, J. T., Khandelwal, A., SantaMaria, A. M., ... Burke, M. D. (2023). Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature, 623(7989), 1079-1085. https://doi.org/10.1038/s41586-023-06710-4
Ghosh, S., Yang, R., Duraki, D., Zhu, J., Kim, J. E., Jabeen, M., Mao, C., Dai, X., Livezey, M. R., Boudreau, M. W., Park, B. H., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2023). Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis. Cancer Research, 83(18), 3115-3130. https://doi.org/10.1158/0008-5472.CAN-23-0157
Gapinske, M., Winter, J., Swami, D., Gapinske, L., Woods, W. S., Shirguppe, S., Miskalis, A., Busza, A., Joulani, D., Kao, C. J., Kostan, K., Bigot, A., Bashir, R., & Perez-Pinera, P. (2023). Targeting Duchenne muscular dystrophy by skipping DMD exon 45 with base editors. Molecular Therapy - Nucleic Acids, 33, 572-586. https://doi.org/10.1016/j.omtn.2023.07.029
Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M., & Barger, A. M. (2023). Acute phase protein concentrations following serial procaine penicillin G injections in horses. Equine veterinary journal, 55(5), 916-922. https://doi.org/10.1111/evj.13886
Corbet, A. K., Bikorimana, E., Boyd, R. I., Shokry, D., Kries, K., Gupta, A., Paton, A., Sun, Z., Fazal, Z., Freemantle, S. J., Nelson, E. R., Spinella, M. J., & Singh, R. (2023). G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells. Translational Oncology, 33, Article 101676. https://doi.org/10.1016/j.tranon.2023.101676
Baur, B., Shin, J., Schreiber, J., Zhang, S., Zhang, Y., Manjunath, M., Song, J. S., Noble, W. S., & Roy, S. (2023). Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation. PLoS computational biology, 19(7), Article e1011286. https://doi.org/10.1371/journal.pcbi.1011286
Stinson, J. A., Sheen, A., Momin, N., Hampel, J., Bernstein, R., Kamerer, R., Fadl-Alla, B., Samuelson, J., Fink, E., Fan, T. M., & Wittrup, K. D. (2023). Collagen-Anchored Interleukin-2 and Interleukin-12 Safely Reprogram the Tumor Microenvironment in Canine Soft-Tissue Sarcomas. Clinical Cancer Research, 29(11), 2110-2122. https://doi.org/10.1158/1078-0432.CCR-23-0006
Ranoa, D. R. E., Sharma, P., Schane, C. P., Lewis, A. N., Valdez, E., Marada, V. V. V. R., Hager, M. V., Montgomery, W., Wolf, S. P., Schreiber, K., Schreiber, H., Bailey, K., Fan, T. M., Hergenrother, P. J., Roy, E. J., & Kranz, D. M. (2023). Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. Journal for ImmunoTherapy of Cancer, 11(5), Article e006509. https://doi.org/10.1136/jitc-2022-006509
Anmangandla, A., Jana, S., Peng, K., Wallace, S. D., Bagde, S. R., Drown, B. S., Xu, J., Hergenrother, P. J., Fromme, J. C., & Lin, H. (2023). A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain. ACS chemical biology, 18(5), 1200-1207. https://doi.org/10.1021/acschembio.3c00092
Miller, J. C., Lee, J. H. Z., Mclean, M. A., Chao, R. R., Stone, I. S. J., Pukala, T. L., Bruning, J. B., De Voss, J. J., Schuler, M. A., Sligar, S. G., & Bell, S. G. (2023). Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society, 145(16), 9207-9222. https://doi.org/10.1021/jacs.3c01456
Putt, K. S., Tarasow, T., Sandhorst, J. S., Hergenrother, P. J., Fako, V. E., & Peterson, Q. P. (2023). Compounds And Methods For The Treatment Of Cancer. (U.S. Patent No. 11612598).
Danciu, O. C., Holdhoff, M., Peterson, R. A., Fischer, J. H., Liu, L. C., Wang, H., Venepalli, N. K., Chowdhery, R., Nicholas, M. K., Russell, M. J., Fan, T. M., Hergenrother, P. J., Tarasow, T. M., & Dudek, A. Z. (2023). Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies. British Journal of Cancer, 128(5), 783-792. https://doi.org/10.1038/s41416-022-02089-7
Hergenrother, P. J., Shapiro, D. J., & Boudreau, M. W. (2023). Activators Of The Unfolded Protein Response. (U.S. Patent No. 11584718).
Kwon, J. Y., Moskwa, N., Kang, W., Fan, T. M., & Lee, C. (2023). Canine as a Comparative and Translational Model for Human Mammary Tumor. Journal of Breast Cancer, 26(1), 1-13. https://doi.org/10.4048/jbc.2023.26.e4
Zhang, X., Flaws, J. A., Spinella, M. J., & Irudayaraj, J. (2023). The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease. Toxics, 11(1), Article 32. https://doi.org/10.3390/toxics11010032
Wang, J., Su, X., Jiang, L., Boudreau, M. W., Chatkewitz, L. E., Kilgore, J. A., Zahid, K. R., Williams, N. S., Chen, Y., Liu, S., Hergenrother, P. J., & Huang, X. (2023). Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers, 15(24). https://doi.org/10.3390/cancers15245844
Kim, S., Yuan, J. B., Woods, W. S., Newton, D. A., Perez-Pinera, P., & Song, J. S. (2023). Chromatin structure and context-dependent sequence features control prime editing efficiency. Frontiers in Genetics, 14, Article 1222112. https://doi.org/10.3389/fgene.2023.1222112
Lichtor, T., Tang, B., & Roy, E. J. (2023). Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor. Brain Sciences, 13(11). https://doi.org/10.3390/brainsci13111505
Lim, C. K. W., Miskalis, A. J., Perez-Pinera, P., & Gaj, T. (2023). Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors. In Methods in Molecular Biology (pp. 135-158). (Methods in Molecular Biology; Vol. 2606). Humana Press Inc.. https://doi.org/10.1007/978-1-0716-2879-9_11
Holdhoff, M., Nicholas, M. K., Peterson, R. A., Maraka, S., Liu, L. C., Fischer, J. H., Wefel, J. S., Fan, T. M., Vannorsdall, T., Russell, M., Iacoboni, M., Tarasow, T. M., Hergenrother, P. J., Dudek, A. Z., & Danciu, O. C. (2023). Phase I dose escalation study of procaspase-activating compound-1 (PAC-1) in combination with temozolomide in patients with recurrent high-grade astrocytomas. Neuro-Oncology Advances, 5(1), Article vdad087. https://doi.org/10.1093/noajnl/vdad087
Song, J. S., & Manjunath, M. (2023). Predicting the molecular functions of regulatory genetic variants associated with cancer. Oncotarget, 14, 775-777. https://doi.org/10.18632/oncotarget.28451
Burke, M. D., Fan, T. M., Hergenrother, P. J., Brooke, C. B., Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., & Wang, L. (2022). Saliva-based Molecular Testing For SARS-CoV-2. (U.S. Patent No. 11530457).
Lim, C. K. W., McCallister, T. X., Saporito-Magriña, C., McPheron, G. D., Krishnan, R., Zeballos C, M. A., Powell, J. E., Clark, L. V., Perez-Pinera, P., & Gaj, T. (2022). CRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes. Molecular Therapy, 30(12), 3619-3631. https://doi.org/10.1016/j.ymthe.2022.08.008
Jain, I., Berg, I. C., Acharya, A., Blaauw, M., Gosstola, N., Perez-Pinera, P., & Underhill, G. H. (2022). Delineating cooperative effects of Notch and biomechanical signals on patterned liver differentiation. Communications biology, 5(1), [1073]. https://doi.org/10.1038/s42003-022-03840-9
Berry, M. R., Fadl-Alla, B. A., Samuelson, J., Rosol, T. J., & Fan, T. M. (2022). Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection. BMC Veterinary Research, 18(1), [441]. https://doi.org/10.1186/s12917-022-03544-6
Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G., ... Burke, M. D. (2022). Mitigation of SARS-CoV-2 transmission at a large public university. Nature communications, 13(1), [3207]. https://doi.org/10.1038/s41467-022-30833-3
Tarasow, T., Peh, J., Hergenrother, P. J., & Boudreau, M. W. (2022). Cancer Therapy By Degrading Dual Mek Signaling. (U.S. Patent No. 11510919).
Nelczyk, A. T., Ma, L., Gupta, A. D., Gamage, H. E. V., McHenry, M. T., Henn, M. A., Kadiri, M., Wang, Y., Krawczynska, N., Bendre, S., He, S., Shahoei, S. H., Madak-Erdogan, Z., Hsiao, S. H., Saleh, T., Carpenter, V., Gewirtz, D. A., Spinella, M. J., & Nelson, E. R. (2022). The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1868(11), [166515]. https://doi.org/10.1016/j.bbadis.2022.166515
Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M., & Barger, A. M. (2022). Acute phase protein concentrations following serial procaine penicillin G injections in horses. Equine veterinary journal. https://doi.org/10.1111/evj.13886
Ren, P., Tiede, C., Fanning, S. W., Adams, T., Speirs, V., Nelson, E. R., Cheng, C., Moore, T. W., Greene, G. L., Tomlinson, D., & Selvin, P. R. (2022). Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line. Biophysical journal, 121(19), 3651-3662. https://doi.org/10.1016/j.bpj.2022.06.028
LeBlanc, A. K., Mazcko, C. N., Fan, T. M., Vail, D. M., Flesner, B. K., Bryan, J. N., Li, S., Wang, F., Harris, S., Vargas, J. D., Govindharajulu, J. P., Jaganathan, S., Tomaino, F., Srivastava, A. K., Chou, T. F., Stott, G. M., Covey, J. M., Mroczkowski, B., & Doroshow, J. H. (2022). Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs. Molecular Cancer Therapeutics, 21(10), 1510-1523. https://doi.org/10.1158/1535-7163.MCT-22-0167
Muñoz, K. A., & Hergenrother, P. J. (2022). Computational discovery of dynobactin antibiotics. Nature Microbiology, 7(10), 1512-1513. https://doi.org/10.1038/s41564-022-01234-5
Fan, T. M., Garrett, L. D., Selting, K. A., & Constable, P. D. (2022). Novel immunotherapy offers promising weapon against canine melanoma. American journal of veterinary research, 83(10). https://doi.org/10.2460/ajvr.22.08.0133
Parker, E. N., Cain, B. N., Hajian, B., Ulrich, R. J., Geddes, E. J., Barkho, S., Lee, H. Y., Williams, J. D., Raynor, M., Caridha, D., Zaino, A., Rohde, J. M., Zak, M., Shekhar, M., Muñoz, K. A., Rzasa, K. M., Temple, E. R., Hunt, D., Jin, X., ... Hergenrother, P. J. (2022). Erratum: An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections (ACS Central Science (2022) 8:8 (1145-1158) DOI: 10.1021/acscentsci.2c00598). ACS Central Science, 8(9), 1362. https://doi.org/10.1021/acscentsci.2c00969
Parker, E. N., Cain, B. N., Hajian, B., Ulrich, R. J., Geddes, E. J., Barkho, S., Lee, H. Y., Williams, J. D., Raynor, M., Caridha, D., Zaino, A., Shekhar, M., Muñoz, K. A., Rzasa, K. M., Temple, E. R., Hunt, D., Jin, X., Vuong, C., Pannone, K., ... Hergenrother, P. J. (2022). An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections. ACS Central Science, 8(8), 1145-1158. https://doi.org/10.1021/acscentsci.2c00598
Zhang, S., Leistico, J. R., Cho, R. J., Cheng, J. B., & Song, J. S. (2022). Spectral clustering of single-cell multi-omics data on multilayer graphs. Bioinformatics, 38(14), 3600-3608. https://doi.org/10.1093/bioinformatics/btac378
Kelly, A. M., Berry, M. R., Tasker, S. Z., McKee, S. A., Fan, T. M., & Hergenrother, P. J. (2022). Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. Journal of the American Chemical Society, 144(27), 12367-12380. https://doi.org/10.1021/jacs.2c03944
Ma, L., Vidana Gamage, H. E., Tiwari, S., Han, C., Henn, M. A., Krawczynska, N., Dibaeinia, P., Koelwyn, G. J., Das Gupta, A., Bautista Rivas, R. O., Wright, C. L., Xu, F., Moore, K. J., Sinha, S., & Nelson, E. R. (2022). The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells. Endocrinology (United States), 163(7), [bqac072]. https://doi.org/10.1210/endocr/bqac072
Boyd, R. I., Ahmad, S., Singh, R., Fazal, Z., Prins, G. S., Erdogan, Z. M., Irudayaraj, J., & Spinella, M. J. (2022). Toward a Mechanistic Understanding of Poly-and Perfluoroalkylated Substances and Cancer. Cancers, 14(12), [2919]. https://doi.org/10.3390/cancers14122919
Boudreau, M. W., & Hergenrother, P. J. (2022). Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity. RSC Medicinal Chemistry, 13(6), 711-725. https://doi.org/10.1039/d2md00110a
Barger, A., Baker, K., Driskell, E., Sander, W., Roady, P., Berry, M., Schnelle, A., & Fan, T. M. (2022). The use of alkaline phosphatase and runx2 to distinguish osteosarcoma from other common malignant primary bone tumors in dogs. Veterinary pathology, 59(3), 427-432. https://doi.org/10.1177/03009858221083035
Bhattacharjee, A., Johnson, E., Perez-Pinera, P., & Jensen, K. (2022). Development and Implementation of a Remote Enzyme Kinetics Laboratory Exercise. Journal of Microbiology and Biology Education, 23(1). https://doi.org/10.1128/jmbe.00286-21
Song, K., Minami, J. K., Huang, A., Dehkordi, S. R., Lomeli, S. H., Luebeck, J., Goodman, M. H., Moriceau, G., Krijgsman, O., Dharanipragada, P., Ridgley, T., Crosson, W. P., Salazar, J., Pazol, E., Karin, G., Jayaraman, R., Balanis, N. G., Alhani, S., Sheu, K., ... Graeber, T. G. (2022). Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges. Cancer Discovery, 12(4), 1046-1069. https://doi.org/10.1158/2159-8290.CD-20-0936
Lowerison, M., Zhang, W., Chen, X., Fan, T., & Song, P. (2022). Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts. IEEE Transactions on Biomedical Engineering, 69(4), 1449 - 1460. https://doi.org/10.1109/TBME.2021.3119280
Hergenrother, P. J., & Riley, A. (2022). Topoisomerase inhibitors with antibacterial and anticancer activity. (U.S. Patent No. 11274106).
Boudreau, M. W., Mulligan, M. P., Shapiro, D. J., Fan, T. M., & Hergenrother, P. J. (2022). Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry, 65(5), 3894-3912. https://doi.org/10.1021/acs.jmedchem.1c01730
Zhang, L., Dutta, S., Xiong, S., Chan, M., Chan, K. K., Fan, T. M., Bailey, K. L., Lindeblad, M., Cooper, L. M., Rong, L., Gugliuzza, A. F., Shukla, D., Procko, E., Rehman, J., & Malik, A. B. (2022). Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants. Nature chemical biology, 18(3), 342-351. https://doi.org/10.1038/s41589-021-00965-6
Deng, H., Konopka, C. J., Prabhu, S., Sarkar, S., Medina, N. G., Fayyaz, M., Arogundade, O. H., Vidana Gamage, H. E., Shahoei, S. H., Nall, D., Youn, Y., Dobrucka, I. T., Audu, C. O., Joshi, A., Melvin, W. J., Gallagher, K. A., Selvin, P. R., Nelson, E. R., Dobrucki, L. W., ... Smith, A. M. (2022). Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ. ACS Nano, 16(2), 1999-2012. https://doi.org/10.1021/acsnano.1c07010
Vasan, A. K., Haloi, N., Ulrich, R. J., Metcalf, M. E., Wen, P. C., Metcalf, W. W., Hergenrother, P. J., Shukla, D., & Tajkhorshid, E. (2022). Role of internal loop dynamics in antibiotic permeability of outer membrane porins. Proceedings of the National Academy of Sciences of the United States of America, 119(8), [e2117009119]. https://doi.org/10.1073/pnas.2117009119
Svec, R. L., Mckee, S. A., Berry, M. R., Kelly, A. M., Fan, T. M., & Hergenrother, P. J. (2022). Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. ACS chemical biology, 17(2), 299–313. https://doi.org/10.1021/acschembio.2c00022
Ma, L., Cho, W., & Nelson, E. R. (2022). Our evolving understanding of how 27-hydroxycholesterol influences cancer. Biochemical Pharmacology, 196, [114621]. https://doi.org/10.1016/j.bcp.2021.114621
Benoit-Lizon, I., Jacquin, E., Rivera Vargas, T., Richard, C., Roussey, A., Dal Zuffo, L., Martin, T., Melis, A., Vinokurova, D., Shahoei, S. H., Baeza Garcia, A., Pignol, C., Giorgiutti, S., Carapito, R., Boidot, R., Végran, F., Flavell, R. A., Ryffel, B., Nelson, E. R., ... Apetoh, L. (2022). CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells. Journal for ImmunoTherapy of Cancer, 10(1), [e003459]. https://doi.org/10.1136/jitc-2021-003459
Shoaib, Z., Fan, T. M., & Irudayaraj, J. M. K. (2022). Osteosarcoma mechanobiology and therapeutic targets. British Journal of Pharmacology, 179(2), 201-217. https://doi.org/10.1111/bph.15713
Applegate, C. C., Deng, H., Kleszynski, B. L., Cross, T. W. L., Konopka, C. J., Dobrucki, L. W., Nelson, E. R., Wallig, M. A., Smith, A. M., & Swanson, K. S. (2022). Impact of administration route on nanocarrier biodistribution in a murine colitis model. Journal of Experimental Nanoscience, 17(1), 599-616. https://doi.org/10.1080/17458080.2022.2134563
Wen, Y., Rashid, F., Fazal, Z., Singh, R., Spinella, M. J., & Irudayaraj, J. (2022). Nephrotoxicity of perfluorooctane sulfonate (PFOS) - effect on transcription and epigenetic factors. Environmental Epigenetics, 8(1), [dvac010]. https://doi.org/10.1093/eep/dvac010
Cavalcanti, J. V. J., Selting, K. A., Ngo, M. T., Hoang, C. K. T., Schaeffer, D. J., Fan, T. M., Harley, B. A. C., & Phillips, H. (2022). Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines. American journal of veterinary research, 83(6). https://doi.org/10.2460/ajvr.21.10.0157
Luo, M., Bao, L., Chen, Y., Xue, Y., Wang, Y., Zhang, B., Wang, C., Corley, C. D., McDonald, J. G., Kumar, A., Xing, C., Fang, Y., Nelson, E. R., Wang, J. E., Wang, Y., & Luo, W. (2022). ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells. Science Advances, 8(28), [abn5295]. https://doi.org/10.1126/sciadv.abn5295
Yokoyama, S., Takahashi, A., Kikuchi, R., Nishibu, S., Lo, J. A., Hejna, M., Moon, W. M., Kato, S., Zhou, Y., Hodi, F. S., Song, J. S., Sakurai, H., Fisher, D. E., & Hayakawa, Y. (2021). SOX10 Regulates Melanoma Immunogenicity through an IRF4–IRF1 Axis. Cancer Research, 81(24), 6131-6141. https://doi.org/10.1158/0008-5472.CAN-21-2078
Haloi, N., Vasan, A. K., Geddes, E. J., Prasanna, A., Wen, P., Metcalf, W. W., Hergenrother, P. J., & Tajkhorshid, E. (2021). Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge. Chemical Science, 12(45), 15028-15044. https://doi.org/10.1039/D1SC04445A
Bulut-Karslioglu, A., Jin, H., Kim, Y. K., Cho, B., Guzman-Ayala, M., Williamson, A. J. K., Hejna, M., Stötzel, M., Whetton, A. D., Song, J. S., & Ramalho-Santos, M. (2021). Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells. Nature communications, 12(1), [4859]. https://doi.org/10.1038/s41467-021-25088-3
Tonnus, W., Meyer, C., Steinebach, C., Belavgeni, A., von Mässenhausen, A., Gonzalez, N. Z., Maremonti, F., Gembardt, F., Himmerkus, N., Latk, M., Locke, S., Marschner, J., Li, W., Short, S., Doll, S., Ingold, I., Proneth, B., Daniel, C., Kabgani, N., ... Linkermann, A. (2021). Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nature communications, 12(1), [4402]. https://doi.org/10.1038/s41467-021-24712-6
Alexander, C., Cross, T. W. L., Lee, A. H., Ly, L. K., Vieson, M. D., Ridlon, J. M., Nelson, E. R., & Swanson, K. S. (2021). Development of a novel model of cholecystectomy in subsequently ovariectomized mice and characterization of metabolic and gastrointestinal phenotypes: a pilot study. BMC Gastroenterology, 21(1), [62]. https://doi.org/10.1186/s12876-021-01648-1
Von Rueden, S. K., & Fan, T. M. (2021). Cancer-Immunity Cycle and Therapeutic Interventions- Opportunities for Including Pet Dogs With Cancer. Frontiers in Oncology, 11, [773420]. https://doi.org/10.3389/fonc.2021.773420
Rowles, J. L., Wallig, M. A., Selting, K. A., Fan, T. M., Miller, R. J., O'Brien, W. D., & Erdman, J. W. (2021). A 10% Tomato Diet Selectively Reduces Radiation-Induced Damage in TRAMP Mice. The Journal of nutrition, 151(11), 3421-3430. https://doi.org/10.1093/jn/nxab257
Nelson, A. T., Wang, Y., & Nelson, E. R. (2021). TLX, an orphan nuclear receptor with emerging roles in physiology and disease. Endocrinology, 162(11). https://doi.org/10.1210/endocr/bqab184
Imir, O. B., Kaminsky, A. Z., Zuo, Q-Y., Liu, Y-J., Singh, R., Spinella, M. J., Irudayaraj, J., Hu, W-Y., Prins, G. S., & Madak Erdogan, Z. (2021). Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression. Nutrients, 13(11), [3902]. https://doi.org/10.3390/nu13113902
Berry, M. R., & Fan, T. M. (2021). Target-Based Radiosensitization Strategies: Concepts and Companion Animal Model Outlook. Frontiers in Oncology, 11, [768692]. https://doi.org/10.3389/fonc.2021.768692
Svec, R. L., & Hergenrother, P. J. (2021). Corrigendum to: Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations (Angewandte Chemie International Edition, (2020), 59, 5, (1857-1862), 10.1002/anie.201911896). Angewandte Chemie - International Edition, 60(41), 22107. https://doi.org/10.1002/anie.202111676
Tonogai, E. J., Huang, S., Botham, R. C., Berry, M. R., Joslyn, S. K., Daniel, G. B., Chen, Z., Rao, J., Zhang, X., Basuli, F., Rossmeisl, J. H., Riggins, G. J., LeBlanc, A. K., Fan, T. M., & Hergenrother, P. J. (2021). Evaluation of a Procaspase-3 Activator with Hydroxyurea or Temozolomide Against High-grade Meningioma in Cell Culture and Canine Cancer Patients. Neuro-Oncology, 23(10), 1723-1735. https://doi.org/10.1093/neuonc/noab161
Geddes, E. J., Li, Z., & Hergenrother, P. J. (2021). An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli. Nature Protocols, 16(10), 4833-4854. https://doi.org/10.1038/s41596-021-00598-y
Peh, J., & Hergenrother, P. J. (2021). PAC-1 combination therapy. (U.S. Patent No. 11129830).
Gupta, A. D., Krawczynska, N., & Nelson, E. R. (2021). Extracellular vesicles — The next frontier in endocrinology. Endocrinology (United States), 162(9), [bqab133]. https://doi.org/10.1210/endocr/bqab133
Levitin, H. A., Foss, K. D., Li, Z., Reinhart, J. M., Hague, D. W., & Fan, T. M. (2021). Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology. Journal of Veterinary Pharmacology and Therapeutics, 44(5), 696-704. https://doi.org/10.1111/jvp.12980
Boyko, Y. D., Huck, C. J., Ning, S., Shved, A. S., Yang, C., Chu, T., Tonogai, E. J., Hergenrother, P. J., & Sarlah, D. (2021). Erratum: Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques (J. Am. Chem. Soc. (2021) 143:4 (2138-2155) DOI: 10.1021/jacs.0c12569). Journal of the American Chemical Society, 143(31), 12418. https://doi.org/10.1021/jacs.1c07261
Lundberg, A. P., Boudreau, M. W., Selting, K. A., Chatkewitz, L. E., Samuelson, J., Francis, J. M., Parkinson, E. I., Barger, A. M., Hergenrother, P. J., & Fan, T. M. (2021). Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy. Neoplasia (United States), 23(8), 811-822. https://doi.org/10.1016/j.neo.2021.06.008
Bhattacharjee, A., Jawad, M., Johnson, E. M., Busza, A. M., Lehmann, R. J., David, B. M., Perez-Pinera, P., & Jensen, K. (2021). Adapting a Cell and Tissue Engineering Laboratory Course to an Online Delivery Format. ASEE Annual Conference and Exposition, Conference Proceedings. https://doi.org/10.18260/1-2--36647
Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2021). A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science Translational Medicine, 13(603), [eabf1383]. https://doi.org/10.1126/scitranslmed.abf1383
Furiassi, L., Tonogai, E. J., & Hergenrother, P. J. (2021). Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity. Angewandte Chemie - International Edition, 60(29), 16119-16128. https://doi.org/10.1002/anie.202104228
Baek, A. E., Krawczynska, N., Das Gupta, A., Dvoretskiy, S. V., You, S., Park, J., Deng, Y-H., Sorrells, J. E., Smith, B. P., Ma, L., Nelson, A. T., McDowell, H. B., Sprenger, A., Henn, M. A., Madak-Erdogan, Z., Kong, H., Boppart, S. A., Boppart, M. D., & Nelson, E. R. (2021). The Cholesterol Metabolite 27HC Increases Secretion of Extracellular Vesicles Which Promote Breast Cancer Progression. Endocrinology, 162(7), [bqab095]. https://doi.org/10.1210/endocr/bqab095
Hergenrother, P., Shapiro, D. J., & Boudreau, M. W. (2021). Activators of the unfolded protein response. (U.S. Patent No. 11046647).
LeBlanc, A. K., Mazcko, C. N., Cherukuri, A., Berger, E. P., Kisseberth, W. C., Brown, M. E., Lana, S. E., Weishaar, K., Flesner, B. K., Bryan, J. N., Vail, D. M., Burton, J. H., Willcox, J. L., Mutsaers, A. J., Woods, J. P., Northrup, N. C., Saba, C., Curran, K. M., Leeper, H., ... Fan, T. M. (2021). Adjuvant sirolimus does not improve outcome in pet dogs receiving standard-of-care therapy for appendicular osteosarcoma: A prospective, randomized trial of 324 dogs. Clinical Cancer Research, 27(11), 3005-3016. https://doi.org/10.1158/1078-0432.CCR-21-0315
Hergenrother, P. J., Drown, B. S., Richter, M. F., Riley, A., Garcia, A., Tasker, S., & Chavez, M. G. (2021). Small molecules active against gram-negative bacteria. (U.S. Patent No. 10995097).
Hutchinson, S. A., Websdale, A., Cioccoloni, G., Røberg-Larsen, H., Lianto, P., Kim, B., Rose, A., Soteriou, C., Pramanik, A., Wastall, L. M., Williams, B. J., Henn, M. A., Chen, J. J., Ma, L., Moore, J. B., Nelson, E., Hughes, T. A., & Thorne, J. L. (2021). Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer. Oncogene, 40(16), 2872-2883. https://doi.org/10.1038/s41388-021-01720-w
Manjunath, M., Yan, J., Youn, Y., Drucker, K. L., Kollmeyer, T. M., McKinney, A. M., Zazubovich, V., Zhang, Y., Costello, J. F., Eckel-Passow, J., Selvin, P. R., Jenkins, R. B., & Song, J. S. (2021). Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors. Neuro-Oncology, 23(4), 638-649. https://doi.org/10.1093/neuonc/noaa248
Luu, A. M., Leistico, J. R., Miller, T., Kim, S., & Song, J. S. (2021). Predicting TCR-Epitope Binding Specificity Using Deep Metric Learning and Multimodal Learning. Genes, 12(4), NA. [572]. https://doi.org/10.3390/genes12040572
Leistico, J. R., Saini, P., Futtner, C. R., Hejna, M., Omura, Y., Soni, P. N., Sandlesh, P., Milad, M., Wei, J. J., Bulun, S., Parker, J. B., Barish, G. D., Song, J. S., & Chakravarti, D. (2021). Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution. Cell Reports, 34(13), [108927]. https://doi.org/10.1016/j.celrep.2021.108927
Muñoz, K. A., & Hergenrother, P. J. (2021). Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria. Accounts of chemical research, 54(6), 1322-1333. https://doi.org/10.1021/acs.accounts.0c00895
Jawad, M. N., Bhattacharjee, A., Lehmann, R., Busza, A., Perez-Pinera, P., & Jensen, K. (2021). Remote Laboratory Exercise to Develop Micropipetting Skills. Journal of Microbiology and Biology Education, 22(1). https://doi.org/10.1128/jmbe.v22i1.2399
Kim, J., Hergenrother, P. J., Movassaghi, M., Boyer, N. C., & Morrison, K. C. (2021). Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment. (U.S. Patent No. 10918735).
Geng, J., Zhang, X., Prabhu, S., Shahoei, S. H., Nelson, E. R., Swanson, K. S., Anastasio, M. A., & Smith, A. M. (2021). 3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue. Science Advances, 7(8), [eabe2480]. https://doi.org/10.1126/sciadv.abe2480
Garcia Chavez, M., Garcia, A., Lee, H. Y., Lau, G. W., Parker, E. N., Komnick, K. E., & Hergenrother, P. J. (2021). Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile. ACS Infectious Diseases, 7(2), 493-505. https://doi.org/10.1021/acsinfecdis.0c00869
Boyko, Y. D., Huck, C. J., Ning, S., Shved, A. S., Yang, C., Chu, T., Tonogai, E. J., Hergenrother, P. J., & Sarlah, D. (2021). Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques. Journal of the American Chemical Society, 143(4), 2138-2155. https://doi.org/10.1021/jacs.0c12569
Polidore, A. L. A., Furiassi, L., Hergenrother, P. J., & Metcalf, W. W. (2021). A phosphonate natural product made by pantoea ananatis is necessary and sufficient for the hallmark lesions of onion center rot. mBio, 12(1), 1-18. [e03402-20]. https://doi.org/10.1128/mBio.03402-20
Prabhu, S., Deng, H., Cross, T. W. L., Shahoei, S. H., Konopka, C. J., Gonzalez Medina, N., Applegate, C. C., Wallig, M. A., Dobrucki, W., Nelson, E. R., Smith, A. M., & Swanson, K. S. (2021). Nanocarriers targeting adipose macrophages increase glucocorticoid anti-inflammatory potency to ameliorate metabolic dysfunction. Biomaterials Science, 9(2), 506-518. https://doi.org/10.1039/d0bm01142h
Handley, M. K., Joshi, A., Fan, T. M., Hergenrother, P. J., Roth, H. S., Gilbert, M. J., Botham, R. C., Riggins, G. J., & Deering, A. (2021). Procaspase 3 activation by combination therapy. (U.S. Patent No. 10888560).
Perlmutter, S. J., Geddes, E. J., Drown, B. S., Motika, S. E., Lee, M. R., & Hergenrother, P. J. (2021). Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums. ACS Infectious Diseases, 7(1), 162-173. https://doi.org/10.1021/acsinfecdis.0c00715
Basu, A., Bobrovnikov, D. G., Qureshi, Z., Kayikcioglu, T., Ngo, T. T. M., Ranjan, A., Eustermann, S., Cieza, B., Morgan, M. T., Hejna, M., Rube, H. T., Hopfner, K-P., Wolberger, C., Song, J. S., & Ha, T. (2021). Measuring DNA mechanics on the genome scale. Nature, 589(7842), 462-467. https://doi.org/10.1038/s41586-020-03052-3
