Mining Microbial Genomes

Publications

Pei, J.; Mitchell, D.A.; Dixon, J.E.; Grishin, N.V. "Expansion of Type II CAAX Proteases Reveals Evolutionary Origin of γ-Secretase Subunit APH-1." J Mol. Biol., 410:18-26 (2011)

Melby, J.O.; Nard, N.J.; Mitchell, D.A. " Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates". Curr. Op. Chem. Biol., 15:369-387 (2011)

Scholz, R.; Molohon, K.J.; Nachtigall, J.; Vater, J.; Markley, A.L.; Sussmuth, R.D.; Mitchell, D.A.*; Borriss, R.*, "Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42", J. Bacteriol.,193:215-224 (2011)

Molloy, E.; Cotter, P.D.; Hill, C.; Mitchell, D.A.; Ross, R.P, “Streptolysin S-like virulence factors: the continuing saga”, Nat. Rev. Microbiol., 9:670 (2011)

Pei, J.; Mitchell, D.A.; Dixon, J.E.; Grishin, N.V. "Expansion of Type II CAAX Proteases Reveals Evolutionary Origin of γ-Secretase Subunit APH-1." J Mol. Biol., 410:18-26 (2011)

Melby, J.O.; Nard, N.J.; Mitchell, D.A. "Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates". Curr. Op. Chem. Biol., 15:369-387 (2011)

Scholz, R.; Molohon, K.J.; Nachtigall, J.; Vater, J.; Markley, A.L.; Sussmuth, R.D.; Mitchell, D.A.*; Borriss, R.*, “Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42”, J. Bacteriol., 193:215-224 (2011)

J.T. Whitteck, P. Malova, S.C. Peck, R.M. Cicchillo, F. Hammerschmidt,* and W.A. van der Donk,* 2011 On the Stereochemistry of 2-Hydroxyethyl phosphonate Dioxygenase J. Am. Chem. Soc. 133: 4236-4239. PMC3069692

V. Agarwal, S.A. Borisova, W.W. Metcalf, W.A. van der Donk, S.K. Nair 2011 Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase Chem. Biol. in press

S.C. Peck, H.A. Cooke, R.M. Cicchillo, Nair, S.K., van der Donk, W.A. 2011 Mechanism and Substrate Recognition of Hydroxyethylphosphonate Dioxygenase Biochemistry  50: 6598-6605.PMC3143709.

Zhang, Q.; van der Donk, W.A.; Liu, W. 2011 Radical-mediated enzymatic methylation: a tale of two SAMs. Accepted with revisions in Acc. Chem. Res.

Gonzalez, D.J.; Lee, S.W.; Hensler, M.E.; Dahesh, S.; Markley, A.L.; Mitchell, D.A.;Banderia, N.; Nizet, V.;Dixon, J.E.; Dorrestein, P.C. "Clostridiolysin S: A post-translationally modiefied biotoxin from Clostridium botulinum", J. Biol. Chem., 285:28220 (2010)

Mitchell, D.A.; Ryabov, A.D.; Kundu, S.; Chanda, A.; Collins, T.J., "Oxidation of pinacyanol chloride by H2O2 catalyzed by FeIII complexed to tetraamidomacrocylic ligand: unusual kinetics and production identification", J. Coord. Chem., 63:2605 (2010)

Haft, D.;Basu, M.; Mitchell, D.A., " Expansion of ribosomally produced natural products: A nitrile hydratase and NIf11-related precursor family", BMC Biol. 8:70 (2010)

Scholz, R.; Molohon, K.; Nachtigall, J.; Vater, J.; Markley, A.; Sussmuth, R.; *Mitchell, D.; Borriss, R. "Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42," Journal of Bacteriology, 2010.

Gonzalez, D.J.; Lee, S.W.; Hensler, M.E.; Dahesh, S.; Markley, A.L.; Mitchell, D.A.; Banderia, N.; Nizet, V.; Dixon, J.E.; Dorrestein, P.C. “Clostridiolysin S: A post-translationally modified biotoxin from Clostridium botulinum”, J. Biol. Chem., 285:28220-28228 (2010)

Mitchell, D.A.; Ryabov, A.D.; Kundu, S.; Chanda, A,; Collins, T.J., "Oxidation of pinacyanol chloride by H2O2 catalyzed by FeIII complexed to tetraamidomacrocyclic ligand: unusual kinetics and product identification", J. Coord. Chem., 63:2605-2618 (2010)

Haft, D.; Basu, M.; Mitchell, D.A., “Expansion of ribosomally produced natural products: A nitrile hydratase- and Nif11-related precursor family”, BMC Biol., 8:70 (2010)Commentary: Schmidt, E.W.; “The hidden diversity of ribosomal peptide natural products” BMC Biol., 8:83 (2010)

Mitchell, D.A.; Lee, S.W.; Pence, M.A.; Markley, A.L.; Limm, J.D.; Nizet, V.; Dixon, J.E., "Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S", J. Biol. Chem., 284:13004-13012 (2009)

Mitchell, D.A.; Lee, S.W.; Pence, M.A.; Markley, A.L.; Limm, J.D.; Nizet, V.; Dixon, J.E., “Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S”, J. Biol. Chem., 284:13004-13012 (2009)

Ghosh, A.; Mitchell, D.A.; Chanda, A.; Ryabov, A.D.; Popescu, D.L.; Upham, E.; Collins, T.J., “Catalase-Peroxidase Activity of Iron(III)-TAML Activators of Hydrogen Peroxide” J. Am. Chem. Soc., 130:15116-15126 (2008)

Lee, S.W.* and Mitchell, D.A.*; Markley, A.L.; Hensler, M.E.; Gonzalez, D.; Wohlrab, A.; Dorrestein, P.C.; Nizet, V.; Dixon, J.E., “Discovery of a Widely Distributed Toxin Biosynthetic Gene Cluster” Proc. Natl. Acad. Sci. USA, 105: 5879-5884 (2008) *These authors contributed equally to this workCommentary: Walsh, C.T.; Nolan, E.M., “Morphing Peptide Backbones into Heterocycles” Proc. Natl. Acad. Sci. USA, 105:5655-5656 (2008)

Ghosh, A.; Mitchell, D.A.; Chanda, A.; Ryabov, A.D.; Popescu, D.L.; Upham, E.; Collins, T.J., "Catalase-Peroxidase Activity of Iron(III)-TAML Activators of Hydrogen Peroxide" J. Am. Chem. Soc., 130:15116-15126 (2008)

Lee, S.W.*and Mitchell, D.A.*; Markley, A.L.; Hensler, M.E.; Gonzalez, D.; Wohlrab, A.; Dorrestein, P.C.; Nizet, V.; Dixon, J.E., "Discovery of a Widely Distributed Toxin Biosynthetic Gene Cluster" Proc. Natl. Acad. Sci. USA, 105: 5879-5884 (2008)*These authors contributed equally to this work

Mitchell, D.A.; Morton, S.U.; Fernhoff, N.B.; Marletta, M.A., "Thioredoxin is Required for S-Nitrosation of Procaspase-3 and Inhibits Apoptosis in Jurkat Cells" Proc. Natl. Acad. Sci. USA, 104: 11609-11614 (2007)

Mitchell, D.A.; Morton, S.U.; Fernhoff, N.B.; Marletta, M.A., “Thioredoxin is Required for S-Nitrosation of Procaspase-3 and Inhibits Apoptosis in Jurkat Cells” Proc. Natl. Acad. Sci. USA, 104:11609-11614 (2007)

Chahbane, N.; Popescu, D.L.; Mitchell, D.A.; Chanda, A.; Lenoir, D.; Ryabov, A.D.; Schramm, K.W.; Collins, T.J., “Fe(III)-TAML Catalyzed Green Oxidative Degradation of the Azo Dye Orange II by H2O2 and Organic Peroxides: Products, Toxicity, Kinetics, and Mechanisms” Green Chem., 9:1-10 (2007)

Mitchell, D.A.; Morton, S.U.; Marletta, M.A., “Design and Characterization of an Active Site Selective Caspase-3 Transnitrosating Agent” ACS Chem. Biol., 1:659-665 (2006)Point of View: Tannenbaum, S.R. and White, F.M., “Regulation and Specificity of S-Nitrosylation and Denitrosylation” ACS Chem. Biol., 1:615-618 (2006)

Erwin, P.A.; Mitchell, D.A.; Sartoretto, J.; Marletta, M.A.; Michel, T., “Subcellular Targeting and Differential S-Nitrosylation of Endothelial Nitric Oxide Synthase” J. Biol. Chem. 281:151-157 (2006)

Mitchell, D.A. and Marletta, M.A., “Thioredoxin Catalyzes the S-Nitrosation of the Caspase-3 Active Site Cysteine” Nat. Chem. Biol., 1:154-158 (2005)News and Views: Tannenbaum, S.R. and Kim, J., “Controlled S-Nitrosation” Nat. Chem. Biol., 1:126-127 (2005)

Mitchell, D.A.; Erwin, P.A.; Michel, T.; Marletta, M.A., “S-Nitrosation and Regulation of Inducible Nitric Oxide Synthase” Biochemistry, 44:4636-4647 (2005)

Lazo, J.S.; Nemoto, K.; Pestell, K.E.; Cooley, K.; Southwick, E.C.; Mitchell, D.A.; Furey, W.; Gussio, R.; Zaharevitz, D.W.; Joo, B.; Wipf, P., “Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors” Mol. Pharmacol., 61:720-728 (2002)

Mitchell, D.A., Marletta, M.A., Michel, T., “Effects of S-Nitrosation of Nitric Oxide Synthase Isoforms” (Review) Adv. Exp. Biol, Nitric Oxide 1, Ch. 7.