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Carl R. Woese Institute for Genomic Biology

Where Science Meets Society

University of Illinois awarded $8M from NIH to study nuclear structure

For years genome-mapping technology has understood DNA as a linear code, but that’s not how it exists in the cell: it’s tangled up in 3D inside the nucleus, with higher- and lower-density areas. Moreover, it exists in the fourth dimension as well—gene clusters can shift their positions over time. But what does this differential positioning within nuclei imply, and what does it mean when it changes?

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