UPDATE: The Editorial Board of the Proceedings of the National Academy of Sciences (PNAS) has selected six papers published by PNAS in 2022 to receive the Cozzarelli Prize, an award that recognizes outstanding contributions to the scientific disciplines represented by the National Academy of Sciences (NAS). Papers were chosen from more than 3,200 research articles that appeared in the journal last year and represent the six broadly defined classes under which the NAS is organized.