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PFAS exposure, high-fat diet drive prostate cells’ metabolism into pro-cancer state

November 12, 2021

Exposure to PFAS – a class of synthetic chemicals utilized in food wrappers, nonstick cookware and other products – reprograms the metabolism of benign and malignant human prostate cells to a more energy efficient state that enables the cells to proliferate at three times the rate of nonexposed cells, a new study in mice found.


November 12, 2021


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AI in Cancer Research: Applications of Computational Genomics

September 29, 2021

In bioinformatics, machine learning (ML) tools are used to solve problems in molecular biology and genetics. In healthy cells, genes — the carriers of hereditary information — are switched “on” or “off” to carry out specific tasks. Bioinformatics researchers can decode DNA using artificial intelligence (AI) to understand why some of these switches occur inappropriately, leading to disease.


September 29, 2021


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AI in Cancer Research: Tumor Phylogenetics

September 15, 2021

Artificial intelligence is often employed in the field of cancer genomics, where bits of DNA sequencing data must be identified and further analyzed with statistical, evolutional, and probabilistic models. “Off-the-shelf” computing tools are useful for many cancer researchers, but Mohammed El-Kebir (IGOH), Cancer Center at Illinois (CCIL) scientist, is taking these AI applications a step further.


September 15, 2021


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Exploring RNA Splicing’s Role in Liver Cancer

August 19, 2021

When Auinash Kalsotra (CGD/GNDP), member of the Cancer Center at Illinois, Associate Professor and the William C. Rose Scholar of Biochemistry, attended college at Birla Institute of Technology and Science in India, he knew he wanted to pursue an entrepreneurial career inspired by his family members. Instead of following a traditional business route, Kalsotra’s enterprising genes have led him down a trailblazing scientific journey – uncovering intricacies of cell biological mechanisms that may lead to more targeted and improved cancer therapies.


August 19, 2021


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New approach eradicates breast cancer in mice

July 21, 2021

A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.

Led by scientists at the University of Illinois Urbana-Champaign, the research team reports the findings in the journal Science Translational Medicine.


July 21, 2021


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Cholesterol metabolite induces production of cancer-promoting vesicles

June 9, 2021

Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.


June 9, 2021


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New computational models to understand colon cancer

March 29, 2021

Although the development of secondary cancerous growths, called metastasis, is the primary cause of death in most cancers, the cellular changes that drive it are poorly understood. In a new study, published in Genome Biology, researchers at the University of Illinois Urbana-Champaign have developed a new modeling approach to better understand how tumors become aggressive.


March 29, 2021


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Leading New Directions in Cancer Research: The Unanswered Black Box

March 11, 2021

Hyunjoon Kong (M-CELS leader/EIRH/RBTE), Robert W. Schafer professor of chemical and biomolecular engineering, approaches cancer research from a perspective that integrates cell engineering and biomaterials. The Kong research team has been working with Georgia Tech University and Massachusetts Institute of Technology (MIT) over the past 10 years under the National Science Foundation (NSF) Science and Technology Center Grant.


March 11, 2021


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