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Anticancer Discovery from Pets to People: Publications

Geddes, E. J., Gugger, M., Garcia, A., Garcia Chavez, M., Lee, M. R., Perlmutter, S. J., Bieniossek, C., Guasch, L., & Hergenrother, P. (2023). Porin-independent accumulation in Pseudomonas enables antibiotic discovery. Nature, 624(7990), 145-153.

Boudreau, M. W., Tonogai, E. J., Schane, C. P., Xi, M. X., Fischer, J. H., Vijayakumar, J., Ji, Y., Tarasow, T. M., Fan, T. M., Hergenrother, P. J., & Dudek, A. Z. (2023). The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma. Melanoma research, 33(6), 514-524.

Yu, L., Xu, L., Chu, H., Peng, J., Sacharidou, A., Hsieh, H. H., Weinstock, A., Khan, S., Ma, L., Durán, J. G. B., McDonald, J., Nelson, E. R., Park, S., McDonnell, D. P., Moore, K. J., Huang, L. J. S., Fisher, E. A., Mineo, C., Huang, L., & Shaul, P. W. (2023). Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nature communications, 14(1), Article 4101.

Maji, A., Soutar, C. P., Zhang, J., Lewandowska, A., Uno, B. E., Yan, S., Shelke, Y., Murhade, G., Nimerovsky, E., Borcik, C. G., Arango, A. S., Lange, J. D., Marin-Toledo, J. P., Lyu, Y., Bailey, K. L., Roady, P. J., Holler, J. T., Khandelwal, A., SantaMaria, A. M., ... Burke, M. D. (2023). Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature, 623(7989), 1079-1085.

Ghosh, S., Yang, R., Duraki, D., Zhu, J., Kim, J. E., Jabeen, M., Mao, C., Dai, X., Livezey, M. R., Boudreau, M. W., Park, B. H., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2023). Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis. Cancer Research, 83(18), 3115-3130.

Gapinske, M., Winter, J., Swami, D., Gapinske, L., Woods, W. S., Shirguppe, S., Miskalis, A., Busza, A., Joulani, D., Kao, C. J., Kostan, K., Bigot, A., Bashir, R., & Perez-Pinera, P. (2023). Targeting Duchenne muscular dystrophy by skipping DMD exon 45 with base editors. Molecular Therapy - Nucleic Acids, 33, 572-586.

Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M., & Barger, A. M. (2023). Acute phase protein concentrations following serial procaine penicillin G injections in horses. Equine veterinary journal, 55(5), 916-922.

Corbet, A. K., Bikorimana, E., Boyd, R. I., Shokry, D., Kries, K., Gupta, A., Paton, A., Sun, Z., Fazal, Z., Freemantle, S. J., Nelson, E. R., Spinella, M. J., & Singh, R. (2023). G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells. Translational Oncology, 33, Article 101676.

Baur, B., Shin, J., Schreiber, J., Zhang, S., Zhang, Y., Manjunath, M., Song, J. S., Noble, W. S., & Roy, S. (2023). Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation. PLoS computational biology, 19(7), Article e1011286.

Stinson, J. A., Sheen, A., Momin, N., Hampel, J., Bernstein, R., Kamerer, R., Fadl-Alla, B., Samuelson, J., Fink, E., Fan, T. M., & Wittrup, K. D. (2023). Collagen-Anchored Interleukin-2 and Interleukin-12 Safely Reprogram the Tumor Microenvironment in Canine Soft-Tissue Sarcomas. Clinical Cancer Research, 29(11), 2110-2122.

Ranoa, D. R. E., Sharma, P., Schane, C. P., Lewis, A. N., Valdez, E., Marada, V. V. V. R., Hager, M. V., Montgomery, W., Wolf, S. P., Schreiber, K., Schreiber, H., Bailey, K., Fan, T. M., Hergenrother, P. J., Roy, E. J., & Kranz, D. M. (2023). Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. Journal for ImmunoTherapy of Cancer, 11(5), Article e006509.

Anmangandla, A., Jana, S., Peng, K., Wallace, S. D., Bagde, S. R., Drown, B. S., Xu, J., Hergenrother, P. J., Fromme, J. C., & Lin, H. (2023). A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain. ACS chemical biology, 18(5), 1200-1207.

Miller, J. C., Lee, J. H. Z., Mclean, M. A., Chao, R. R., Stone, I. S. J., Pukala, T. L., Bruning, J. B., De Voss, J. J., Schuler, M. A., Sligar, S. G., & Bell, S. G. (2023). Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society, 145(16), 9207-9222.

Putt, K. S., Tarasow, T., Sandhorst, J. S., Hergenrother, P. J., Fako, V. E., & Peterson, Q. P. (2023). Compounds And Methods For The Treatment Of Cancer. (U.S. Patent No. 11612598).

Danciu, O. C., Holdhoff, M., Peterson, R. A., Fischer, J. H., Liu, L. C., Wang, H., Venepalli, N. K., Chowdhery, R., Nicholas, M. K., Russell, M. J., Fan, T. M., Hergenrother, P. J., Tarasow, T. M., & Dudek, A. Z. (2023). Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies. British Journal of Cancer, 128(5), 783-792.

Hergenrother, P. J., Shapiro, D. J., & Boudreau, M. W. (2023). Activators Of The Unfolded Protein Response. (U.S. Patent No. 11584718).

Kwon, J. Y., Moskwa, N., Kang, W., Fan, T. M., & Lee, C. (2023). Canine as a Comparative and Translational Model for Human Mammary Tumor. Journal of Breast Cancer, 26(1), 1-13.

Zhang, X., Flaws, J. A., Spinella, M. J., & Irudayaraj, J. (2023). The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease. Toxics, 11(1), Article 32.

Wang, J., Su, X., Jiang, L., Boudreau, M. W., Chatkewitz, L. E., Kilgore, J. A., Zahid, K. R., Williams, N. S., Chen, Y., Liu, S., Hergenrother, P. J., & Huang, X. (2023). Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers, 15(24).

Kim, S., Yuan, J. B., Woods, W. S., Newton, D. A., Perez-Pinera, P., & Song, J. S. (2023). Chromatin structure and context-dependent sequence features control prime editing efficiency. Frontiers in Genetics, 14, Article 1222112.

Lichtor, T., Tang, B., & Roy, E. J. (2023). Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor. Brain Sciences, 13(11).

Lim, C. K. W., Miskalis, A. J., Perez-Pinera, P., & Gaj, T. (2023). Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors. In Methods in Molecular Biology (pp. 135-158). (Methods in Molecular Biology; Vol. 2606). Humana Press Inc..

Holdhoff, M., Nicholas, M. K., Peterson, R. A., Maraka, S., Liu, L. C., Fischer, J. H., Wefel, J. S., Fan, T. M., Vannorsdall, T., Russell, M., Iacoboni, M., Tarasow, T. M., Hergenrother, P. J., Dudek, A. Z., & Danciu, O. C. (2023). Phase I dose escalation study of procaspase-activating compound-1 (PAC-1) in combination with temozolomide in patients with recurrent high-grade astrocytomas. Neuro-Oncology Advances, 5(1), Article vdad087.

Song, J. S., & Manjunath, M. (2023). Predicting the molecular functions of regulatory genetic variants associated with cancer. Oncotarget, 14, 775-777.

Burke, M. D., Fan, T. M., Hergenrother, P. J., Brooke, C. B., Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., & Wang, L. (2022). Saliva-based Molecular Testing For SARS-CoV-2. (U.S. Patent No. 11530457).

Lim, C. K. W., McCallister, T. X., Saporito-Magriña, C., McPheron, G. D., Krishnan, R., Zeballos C, M. A., Powell, J. E., Clark, L. V., Perez-Pinera, P., & Gaj, T. (2022). CRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes. Molecular Therapy, 30(12), 3619-3631.

Jain, I., Berg, I. C., Acharya, A., Blaauw, M., Gosstola, N., Perez-Pinera, P., & Underhill, G. H. (2022). Delineating cooperative effects of Notch and biomechanical signals on patterned liver differentiation. Communications biology, 5(1), [1073].

Berry, M. R., Fadl-Alla, B. A., Samuelson, J., Rosol, T. J., & Fan, T. M. (2022). Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection. BMC Veterinary Research, 18(1), [441].

Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G., ... Burke, M. D. (2022). Mitigation of SARS-CoV-2 transmission at a large public university. Nature communications, 13(1), [3207].

Tarasow, T., Peh, J., Hergenrother, P. J., & Boudreau, M. W. (2022). Cancer Therapy By Degrading Dual Mek Signaling. (U.S. Patent No. 11510919).

Nelczyk, A. T., Ma, L., Gupta, A. D., Gamage, H. E. V., McHenry, M. T., Henn, M. A., Kadiri, M., Wang, Y., Krawczynska, N., Bendre, S., He, S., Shahoei, S. H., Madak-Erdogan, Z., Hsiao, S. H., Saleh, T., Carpenter, V., Gewirtz, D. A., Spinella, M. J., & Nelson, E. R. (2022). The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1868(11), [166515].

Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M., & Barger, A. M. (2022). Acute phase protein concentrations following serial procaine penicillin G injections in horses. Equine veterinary journal.

Ren, P., Tiede, C., Fanning, S. W., Adams, T., Speirs, V., Nelson, E. R., Cheng, C., Moore, T. W., Greene, G. L., Tomlinson, D., & Selvin, P. R. (2022). Labeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line. Biophysical journal, 121(19), 3651-3662.

LeBlanc, A. K., Mazcko, C. N., Fan, T. M., Vail, D. M., Flesner, B. K., Bryan, J. N., Li, S., Wang, F., Harris, S., Vargas, J. D., Govindharajulu, J. P., Jaganathan, S., Tomaino, F., Srivastava, A. K., Chou, T. F., Stott, G. M., Covey, J. M., Mroczkowski, B., & Doroshow, J. H. (2022). Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs. Molecular Cancer Therapeutics, 21(10), 1510-1523.

Muñoz, K. A., & Hergenrother, P. J. (2022). Computational discovery of dynobactin antibiotics. Nature Microbiology, 7(10), 1512-1513.

Fan, T. M., Garrett, L. D., Selting, K. A., & Constable, P. D. (2022). Novel immunotherapy offers promising weapon against canine melanoma. American journal of veterinary research, 83(10).

Parker, E. N., Cain, B. N., Hajian, B., Ulrich, R. J., Geddes, E. J., Barkho, S., Lee, H. Y., Williams, J. D., Raynor, M., Caridha, D., Zaino, A., Rohde, J. M., Zak, M., Shekhar, M., Muñoz, K. A., Rzasa, K. M., Temple, E. R., Hunt, D., Jin, X., ... Hergenrother, P. J. (2022). Erratum: An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections (ACS Central Science (2022) 8:8 (1145-1158) DOI: 10.1021/acscentsci.2c00598). ACS Central Science, 8(9), 1362.

Parker, E. N., Cain, B. N., Hajian, B., Ulrich, R. J., Geddes, E. J., Barkho, S., Lee, H. Y., Williams, J. D., Raynor, M., Caridha, D., Zaino, A., Shekhar, M., Muñoz, K. A., Rzasa, K. M., Temple, E. R., Hunt, D., Jin, X., Vuong, C., Pannone, K., ... Hergenrother, P. J. (2022). An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections. ACS Central Science, 8(8), 1145-1158.

Zhang, S., Leistico, J. R., Cho, R. J., Cheng, J. B., & Song, J. S. (2022). Spectral clustering of single-cell multi-omics data on multilayer graphs. Bioinformatics, 38(14), 3600-3608.

Kelly, A. M., Berry, M. R., Tasker, S. Z., McKee, S. A., Fan, T. M., & Hergenrother, P. J. (2022). Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. Journal of the American Chemical Society, 144(27), 12367-12380.

Ma, L., Vidana Gamage, H. E., Tiwari, S., Han, C., Henn, M. A., Krawczynska, N., Dibaeinia, P., Koelwyn, G. J., Das Gupta, A., Bautista Rivas, R. O., Wright, C. L., Xu, F., Moore, K. J., Sinha, S., & Nelson, E. R. (2022). The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells. Endocrinology (United States), 163(7), [bqac072].

Boyd, R. I., Ahmad, S., Singh, R., Fazal, Z., Prins, G. S., Erdogan, Z. M., Irudayaraj, J., & Spinella, M. J. (2022). Toward a Mechanistic Understanding of Poly-and Perfluoroalkylated Substances and Cancer. Cancers, 14(12), [2919].

Boudreau, M. W., & Hergenrother, P. J. (2022). Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity. RSC Medicinal Chemistry, 13(6), 711-725.

Barger, A., Baker, K., Driskell, E., Sander, W., Roady, P., Berry, M., Schnelle, A., & Fan, T. M. (2022). The use of alkaline phosphatase and runx2 to distinguish osteosarcoma from other common malignant primary bone tumors in dogs. Veterinary pathology, 59(3), 427-432.

Bhattacharjee, A., Johnson, E., Perez-Pinera, P., & Jensen, K. (2022). Development and Implementation of a Remote Enzyme Kinetics Laboratory Exercise. Journal of Microbiology and Biology Education, 23(1).

Song, K., Minami, J. K., Huang, A., Dehkordi, S. R., Lomeli, S. H., Luebeck, J., Goodman, M. H., Moriceau, G., Krijgsman, O., Dharanipragada, P., Ridgley, T., Crosson, W. P., Salazar, J., Pazol, E., Karin, G., Jayaraman, R., Balanis, N. G., Alhani, S., Sheu, K., ... Graeber, T. G. (2022). Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges. Cancer Discovery, 12(4), 1046-1069.

Lowerison, M., Zhang, W., Chen, X., Fan, T., & Song, P. (2022). Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts. IEEE Transactions on Biomedical Engineering, 69(4), 1449 - 1460.

Hergenrother, P. J., & Riley, A. (2022). Topoisomerase inhibitors with antibacterial and anticancer activity. (U.S. Patent No. 11274106).

Boudreau, M. W., Mulligan, M. P., Shapiro, D. J., Fan, T. M., & Hergenrother, P. J. (2022). Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. Journal of Medicinal Chemistry, 65(5), 3894-3912.

Zhang, L., Dutta, S., Xiong, S., Chan, M., Chan, K. K., Fan, T. M., Bailey, K. L., Lindeblad, M., Cooper, L. M., Rong, L., Gugliuzza, A. F., Shukla, D., Procko, E., Rehman, J., & Malik, A. B. (2022). Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants. Nature chemical biology, 18(3), 342-351.

Deng, H., Konopka, C. J., Prabhu, S., Sarkar, S., Medina, N. G., Fayyaz, M., Arogundade, O. H., Vidana Gamage, H. E., Shahoei, S. H., Nall, D., Youn, Y., Dobrucka, I. T., Audu, C. O., Joshi, A., Melvin, W. J., Gallagher, K. A., Selvin, P. R., Nelson, E. R., Dobrucki, L. W., ... Smith, A. M. (2022). Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ. ACS Nano, 16(2), 1999-2012.

Vasan, A. K., Haloi, N., Ulrich, R. J., Metcalf, M. E., Wen, P. C., Metcalf, W. W., Hergenrother, P. J., Shukla, D., & Tajkhorshid, E. (2022). Role of internal loop dynamics in antibiotic permeability of outer membrane porins. Proceedings of the National Academy of Sciences of the United States of America, 119(8), [e2117009119].

Svec, R. L., Mckee, S. A., Berry, M. R., Kelly, A. M., Fan, T. M., & Hergenrother, P. J. (2022). Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. ACS chemical biology, 17(2), 299–313.

Ma, L., Cho, W., & Nelson, E. R. (2022). Our evolving understanding of how 27-hydroxycholesterol influences cancer. Biochemical Pharmacology, 196, [114621].

Benoit-Lizon, I., Jacquin, E., Rivera Vargas, T., Richard, C., Roussey, A., Dal Zuffo, L., Martin, T., Melis, A., Vinokurova, D., Shahoei, S. H., Baeza Garcia, A., Pignol, C., Giorgiutti, S., Carapito, R., Boidot, R., Végran, F., Flavell, R. A., Ryffel, B., Nelson, E. R., ... Apetoh, L. (2022). CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of TH1 and TH9 cells. Journal for ImmunoTherapy of Cancer, 10(1), [e003459].

Shoaib, Z., Fan, T. M., & Irudayaraj, J. M. K. (2022). Osteosarcoma mechanobiology and therapeutic targets. British Journal of Pharmacology, 179(2), 201-217.

Applegate, C. C., Deng, H., Kleszynski, B. L., Cross, T. W. L., Konopka, C. J., Dobrucki, L. W., Nelson, E. R., Wallig, M. A., Smith, A. M., & Swanson, K. S. (2022). Impact of administration route on nanocarrier biodistribution in a murine colitis model. Journal of Experimental Nanoscience, 17(1), 599-616.

Wen, Y., Rashid, F., Fazal, Z., Singh, R., Spinella, M. J., & Irudayaraj, J. (2022). Nephrotoxicity of perfluorooctane sulfonate (PFOS) - effect on transcription and epigenetic factors. Environmental Epigenetics, 8(1), [dvac010].

Cavalcanti, J. V. J., Selting, K. A., Ngo, M. T., Hoang, C. K. T., Schaeffer, D. J., Fan, T. M., Harley, B. A. C., & Phillips, H. (2022). Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines. American journal of veterinary research, 83(6).

Luo, M., Bao, L., Chen, Y., Xue, Y., Wang, Y., Zhang, B., Wang, C., Corley, C. D., McDonald, J. G., Kumar, A., Xing, C., Fang, Y., Nelson, E. R., Wang, J. E., Wang, Y., & Luo, W. (2022). ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells. Science Advances, 8(28), [abn5295].

Yokoyama, S., Takahashi, A., Kikuchi, R., Nishibu, S., Lo, J. A., Hejna, M., Moon, W. M., Kato, S., Zhou, Y., Hodi, F. S., Song, J. S., Sakurai, H., Fisher, D. E., & Hayakawa, Y. (2021). SOX10 Regulates Melanoma Immunogenicity through an IRF4–IRF1 Axis. Cancer Research, 81(24), 6131-6141.

Haloi, N., Vasan, A. K., Geddes, E. J., Prasanna, A., Wen, P., Metcalf, W. W., Hergenrother, P. J., & Tajkhorshid, E. (2021). Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge. Chemical Science, 12(45), 15028-15044.

Bulut-Karslioglu, A., Jin, H., Kim, Y. K., Cho, B., Guzman-Ayala, M., Williamson, A. J. K., Hejna, M., Stötzel, M., Whetton, A. D., Song, J. S., & Ramalho-Santos, M. (2021). Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells. Nature communications, 12(1), [4859].

Tonnus, W., Meyer, C., Steinebach, C., Belavgeni, A., von Mässenhausen, A., Gonzalez, N. Z., Maremonti, F., Gembardt, F., Himmerkus, N., Latk, M., Locke, S., Marschner, J., Li, W., Short, S., Doll, S., Ingold, I., Proneth, B., Daniel, C., Kabgani, N., ... Linkermann, A. (2021). Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nature communications, 12(1), [4402].

Alexander, C., Cross, T. W. L., Lee, A. H., Ly, L. K., Vieson, M. D., Ridlon, J. M., Nelson, E. R., & Swanson, K. S. (2021). Development of a novel model of cholecystectomy in subsequently ovariectomized mice and characterization of metabolic and gastrointestinal phenotypes: a pilot study. BMC Gastroenterology, 21(1), [62].

Von Rueden, S. K., & Fan, T. M. (2021). Cancer-Immunity Cycle and Therapeutic Interventions- Opportunities for Including Pet Dogs With Cancer. Frontiers in Oncology, 11, [773420].

Rowles, J. L., Wallig, M. A., Selting, K. A., Fan, T. M., Miller, R. J., O'Brien, W. D., & Erdman, J. W. (2021). A 10% Tomato Diet Selectively Reduces Radiation-Induced Damage in TRAMP Mice. The Journal of nutrition, 151(11), 3421-3430.

Nelson, A. T., Wang, Y., & Nelson, E. R. (2021). TLX, an orphan nuclear receptor with emerging roles in physiology and disease. Endocrinology, 162(11).

Imir, O. B., Kaminsky, A. Z., Zuo, Q-Y., Liu, Y-J., Singh, R., Spinella, M. J., Irudayaraj, J., Hu, W-Y., Prins, G. S., & Madak Erdogan, Z. (2021). Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression. Nutrients, 13(11), [3902].

Berry, M. R., & Fan, T. M. (2021). Target-Based Radiosensitization Strategies: Concepts and Companion Animal Model Outlook. Frontiers in Oncology, 11, [768692].

Svec, R. L., & Hergenrother, P. J. (2021). Corrigendum to: Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations (Angewandte Chemie International Edition, (2020), 59, 5, (1857-1862), 10.1002/anie.201911896). Angewandte Chemie - International Edition, 60(41), 22107.

Tonogai, E. J., Huang, S., Botham, R. C., Berry, M. R., Joslyn, S. K., Daniel, G. B., Chen, Z., Rao, J., Zhang, X., Basuli, F., Rossmeisl, J. H., Riggins, G. J., LeBlanc, A. K., Fan, T. M., & Hergenrother, P. J. (2021). Evaluation of a Procaspase-3 Activator with Hydroxyurea or Temozolomide Against High-grade Meningioma in Cell Culture and Canine Cancer Patients. Neuro-Oncology, 23(10), 1723-1735.

Geddes, E. J., Li, Z., & Hergenrother, P. J. (2021). An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli. Nature Protocols, 16(10), 4833-4854.

Peh, J., & Hergenrother, P. J. (2021). PAC-1 combination therapy. (U.S. Patent No. 11129830).

Gupta, A. D., Krawczynska, N., & Nelson, E. R. (2021). Extracellular vesicles — The next frontier in endocrinology. Endocrinology (United States), 162(9), [bqab133].

Levitin, H. A., Foss, K. D., Li, Z., Reinhart, J. M., Hague, D. W., & Fan, T. M. (2021). Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology. Journal of Veterinary Pharmacology and Therapeutics, 44(5), 696-704.

Boyko, Y. D., Huck, C. J., Ning, S., Shved, A. S., Yang, C., Chu, T., Tonogai, E. J., Hergenrother, P. J., & Sarlah, D. (2021). Erratum: Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques (J. Am. Chem. Soc. (2021) 143:4 (2138-2155) DOI: 10.1021/jacs.0c12569). Journal of the American Chemical Society, 143(31), 12418.

Lundberg, A. P., Boudreau, M. W., Selting, K. A., Chatkewitz, L. E., Samuelson, J., Francis, J. M., Parkinson, E. I., Barger, A. M., Hergenrother, P. J., & Fan, T. M. (2021). Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy. Neoplasia (United States), 23(8), 811-822.

Bhattacharjee, A., Jawad, M., Johnson, E. M., Busza, A. M., Lehmann, R. J., David, B. M., Perez-Pinera, P., & Jensen, K. (2021). Adapting a Cell and Tissue Engineering Laboratory Course to an Online Delivery Format. ASEE Annual Conference and Exposition, Conference Proceedings.

Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2021). A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science Translational Medicine, 13(603), [eabf1383].

Furiassi, L., Tonogai, E. J., & Hergenrother, P. J. (2021). Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity. Angewandte Chemie - International Edition, 60(29), 16119-16128.

Baek, A. E., Krawczynska, N., Das Gupta, A., Dvoretskiy, S. V., You, S., Park, J., Deng, Y-H., Sorrells, J. E., Smith, B. P., Ma, L., Nelson, A. T., McDowell, H. B., Sprenger, A., Henn, M. A., Madak-Erdogan, Z., Kong, H., Boppart, S. A., Boppart, M. D., & Nelson, E. R. (2021). The Cholesterol Metabolite 27HC Increases Secretion of Extracellular Vesicles Which Promote Breast Cancer Progression. Endocrinology, 162(7), [bqab095].

Hergenrother, P., Shapiro, D. J., & Boudreau, M. W. (2021). Activators of the unfolded protein response. (U.S. Patent No. 11046647).

LeBlanc, A. K., Mazcko, C. N., Cherukuri, A., Berger, E. P., Kisseberth, W. C., Brown, M. E., Lana, S. E., Weishaar, K., Flesner, B. K., Bryan, J. N., Vail, D. M., Burton, J. H., Willcox, J. L., Mutsaers, A. J., Woods, J. P., Northrup, N. C., Saba, C., Curran, K. M., Leeper, H., ... Fan, T. M. (2021). Adjuvant sirolimus does not improve outcome in pet dogs receiving standard-of-care therapy for appendicular osteosarcoma: A prospective, randomized trial of 324 dogs. Clinical Cancer Research, 27(11), 3005-3016.

Hergenrother, P. J., Drown, B. S., Richter, M. F., Riley, A., Garcia, A., Tasker, S., & Chavez, M. G. (2021). Small molecules active against gram-negative bacteria. (U.S. Patent No. 10995097).

Hutchinson, S. A., Websdale, A., Cioccoloni, G., Røberg-Larsen, H., Lianto, P., Kim, B., Rose, A., Soteriou, C., Pramanik, A., Wastall, L. M., Williams, B. J., Henn, M. A., Chen, J. J., Ma, L., Moore, J. B., Nelson, E., Hughes, T. A., & Thorne, J. L. (2021). Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer. Oncogene, 40(16), 2872-2883.

Manjunath, M., Yan, J., Youn, Y., Drucker, K. L., Kollmeyer, T. M., McKinney, A. M., Zazubovich, V., Zhang, Y., Costello, J. F., Eckel-Passow, J., Selvin, P. R., Jenkins, R. B., & Song, J. S. (2021). Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors. Neuro-Oncology, 23(4), 638-649.

Luu, A. M., Leistico, J. R., Miller, T., Kim, S., & Song, J. S. (2021). Predicting TCR-Epitope Binding Specificity Using Deep Metric Learning and Multimodal Learning. Genes, 12(4), NA. [572].

Leistico, J. R., Saini, P., Futtner, C. R., Hejna, M., Omura, Y., Soni, P. N., Sandlesh, P., Milad, M., Wei, J. J., Bulun, S., Parker, J. B., Barish, G. D., Song, J. S., & Chakravarti, D. (2021). Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution. Cell Reports, 34(13), [108927].

Muñoz, K. A., & Hergenrother, P. J. (2021). Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria. Accounts of chemical research, 54(6), 1322-1333.

Jawad, M. N., Bhattacharjee, A., Lehmann, R., Busza, A., Perez-Pinera, P., & Jensen, K. (2021). Remote Laboratory Exercise to Develop Micropipetting Skills. Journal of Microbiology and Biology Education, 22(1).

Kim, J., Hergenrother, P. J., Movassaghi, M., Boyer, N. C., & Morrison, K. C. (2021). Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment. (U.S. Patent No. 10918735).

Geng, J., Zhang, X., Prabhu, S., Shahoei, S. H., Nelson, E. R., Swanson, K. S., Anastasio, M. A., & Smith, A. M. (2021). 3D microscopy and deep learning reveal the heterogeneity of crown-like structure microenvironments in intact adipose tissue. Science Advances, 7(8), [eabe2480].

Garcia Chavez, M., Garcia, A., Lee, H. Y., Lau, G. W., Parker, E. N., Komnick, K. E., & Hergenrother, P. J. (2021). Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile. ACS Infectious Diseases, 7(2), 493-505.

Boyko, Y. D., Huck, C. J., Ning, S., Shved, A. S., Yang, C., Chu, T., Tonogai, E. J., Hergenrother, P. J., & Sarlah, D. (2021). Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques. Journal of the American Chemical Society, 143(4), 2138-2155.

Polidore, A. L. A., Furiassi, L., Hergenrother, P. J., & Metcalf, W. W. (2021). A phosphonate natural product made by pantoea ananatis is necessary and sufficient for the hallmark lesions of onion center rot. mBio, 12(1), 1-18. [e03402-20].

Prabhu, S., Deng, H., Cross, T. W. L., Shahoei, S. H., Konopka, C. J., Gonzalez Medina, N., Applegate, C. C., Wallig, M. A., Dobrucki, W., Nelson, E. R., Smith, A. M., & Swanson, K. S. (2021). Nanocarriers targeting adipose macrophages increase glucocorticoid anti-inflammatory potency to ameliorate metabolic dysfunction. Biomaterials Science, 9(2), 506-518.

Handley, M. K., Joshi, A., Fan, T. M., Hergenrother, P. J., Roth, H. S., Gilbert, M. J., Botham, R. C., Riggins, G. J., & Deering, A. (2021). Procaspase 3 activation by combination therapy. (U.S. Patent No. 10888560).

Perlmutter, S. J., Geddes, E. J., Drown, B. S., Motika, S. E., Lee, M. R., & Hergenrother, P. J. (2021). Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums. ACS Infectious Diseases, 7(1), 162-173.

Basu, A., Bobrovnikov, D. G., Qureshi, Z., Kayikcioglu, T., Ngo, T. T. M., Ranjan, A., Eustermann, S., Cieza, B., Morgan, M. T., Hejna, M., Rube, H. T., Hopfner, K-P., Wolberger, C., Song, J. S., & Ha, T. (2021). Measuring DNA mechanics on the genome scale. Nature, 589(7842), 462-467.