One of the biggest challenges in traditional laboratory settings is performing countless hours of error-prone lab work: handling reagents, incubating reactions or living cells, synthesizing products, applying treatments, and monitoring outcomes. The Illinois Biological Foundry for Advanced Biomanufacturing was established in 2014 to bypass these cumbersome procedures and support a broad array of research goals.

On February 25^th 2022, the Illinois General Assembly adopted House Resolution 0690, commending the Carl R. Woese Institute for Genomic Biology on its 15^th year of societal, scientific, and scholarly contributions at the intersection of science and society.

Chemical and biomolecular engineering professor Huimin Zhao (BSD/GSE/CABBI/MMG/CGD) has received the 2022 Food, Pharmaceutical and Bioengineering Division Award in Chemical Engineering from the American Institute of Chemical Engineers (AIChE).

The Publications Division of the American Chemical Society (ACS) has appointed University of Illinois Urbana-Champaign chemical and biomolecular engineering professor Huimin Zhao (CABBI/BSD/GSE/MMG Affiliate, CGD) as editor in chief of ACS Synthetic Biology. Zhao previously served as a founding associate editor of ACS Catalysis, a position he held from 2011–2022.

Plasmids have extensive use in basic and applied biology. These small, circular DNA molecules are used by scientists to introduce new genes into a target organism. Well known for their applications in the production of therapeutic proteins like insulin, plasmids are broadly used in the large-scale production of many bioproducts.

However, designing and constructing plasmids remains one of the most time-consuming and labor-intensive steps in biology research.

Engineering enzymes to perform reactions not found in nature can address longstanding challenges in the world of synthetic chemistry, such as upgrading plant-based oils into useful biochemicals.

Proteins are the molecular machines of all living cells and have been exploited for use in many applications, including therapeutics and industrial catalysts. To overcome the limitations of naturally occurring proteins, protein engineering is used to improve protein characteristics such as stability and functionality. In a new study, researchers demonstrate a machine learning algorithm that accelerates the protein engineering process.

A new coronavirus test can get accurate results from a saliva sample in less than 30 minutes, researchers report in the journal Nature Communications. Many of the components of the hand-held device used in this technology can be 3D-printed, and the test can detect as little as one viral particle per 1-microliter drop of fluid.

Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at Illinois previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.

Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of genetic defects in the heterochromatin.