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Cancer and Companion Animals Focus of New IGB Theme

February 9, 2016

Despite dramatic advances in diagnostics and treatment, cancer still accounts for nearly 1 in 4 U.S. deaths, as well as over half of disease-related pet mortality. Using translational approaches to discover new and effective treatments for both is the goal of new research theme Anticancer Discovery from Pets to People (ACPP) at the Carl R. Woese Institute for Genomic Biology. Led by Professor of Chemistry Paul Hergenrother, ACPP will leverage discoveries proved in companion animals such as cats and dogs with cancer to pioneer new drugs and novel targets to treat human cancers.


February 9, 2016


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New synthetic tumor environments make cancer research more realistic

August 27, 2015

Tumors are notoriously difficult to study in their natural habitat – body tissues – but a new synthetic tissue environment may give cancer researchers the next-best look at tumor growth and behavior.

University of Illinois researchers have developed a new technique to create a cell habitat of squishy fluids, called hydrogels, which can realistically and quickly recreate microenvironments found across biology.


August 27, 2015


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Cancer drug first tested in pet dogs begins human trials

February 26, 2015

Cancer drug first tested in pet dogs begins human trials

A new drug that prompts cancer cells to self-destruct while sparing healthy cells is now entering phase I clinical trials in humans. The drug, called PAC-1, first showed promise in the treatment of pet dogs with spontaneously occurring cancers, and is still in clinical trials in dogs with osteosarcoma.


February 26, 2015


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New research may help doctors personalize cancer treatments

September 26, 2014

New research may help doctors personalize cancer treatments

Most types of tumors, including cancer, require a supply of blood to grow larger than a few millimeters. Scientists have made great progress in combating cancer by finding effective ways to stop the formation of new blood vessels, called angiogenesis.

In four recent papers, University of Illinois Assistant Professor of Bioengineering Princess Imoukhuede and co-authors have made significant progress in personalizing angiogenesis inhibition cancer treatments.  


September 26, 2014


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Researchers Develop New Approach for Studying Deadly Brain Cancer

July 23, 2013

Researchers Develop New Approach for Studying Deadly Brain Cancer

Human glioblastoma multiforme, one of the most common, aggressive and deadly forms of brain cancer, is notoriously difficult to study. Scientists have traditionally studied cancer cells in petri dishes, which have none of the properties of the brain tissues in which these cancers grow, or in expensive animal models.


July 23, 2013


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Cancer Drug Tested in Pet Dogs is Now Bound for Human Trials

July 20, 2013

Cancer Drug Tested in Pet Dogs is Now Bound for Human Trials

Thanks to a new $2 million investment, a drug that spurs cancer cells to self-destruct while sparing healthy cells is on the road to human clinical trials. The compound, known as PAC-1, has so far proven safe and has promising anti-cancer effects in cell culture, in mouse models of cancer and in pet dogs with spontaneously occurring lymphomas and osteosarcomas.


July 20, 2013


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Team discovers how a cancer-causing bacterium spurs cell death

November 1, 2011

Researchers report they have figured out how the cancer-causing bacterium Helicobacter pylori attacks a cell’s energy infrastructure, sparking a series of events in the cell that ultimately lead it to self-destruct.

H. pylori are the only bacteria known to survive in the human stomach. Infection with the bacterium is associated with an increased risk of gastric cancer, the second-leading cause of cancer-related deaths worldwide.


November 1, 2011


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