This is an image of a gelatin methacrylate model for the perivascular niche of the bone marrow. The perivascular niche, defined by proximity to arteriolar and sinusoidal vessels that comprise endothelial and mesenchymal cells within the bone marrow, regulates hematopoietic stem cell proliferation, differentiation, and quiescence through secreted factors, cell-cell interactions, and local remodeling of the bone marrow.
In this image, we have Hoechst 33342-stained nuclei in blue, murine bone marrow-derived mesenchymal stem cells (mMSCs) stained for podoplanin in cyan, and murine bone marrow-derived endothelial cells (mBMECs) stained for CD31 in green.
Gunnar Thompson from the Harley Lab