Images provided by Vladimir Kolossov and Rex Gaskins, Rex Gaskins Lab
Research funded by the National Institutes of Health
All eukaryotic cells contain highly evolved structures called mitochondria, which coordinate energy production and distribution based on the availability of calories, oxygen and the demands for cellular maintenance. In this image, a genetically encoded fluorescent protein was used to detect mitochondria. Bioenergetic reprogramming occurs in many cancer cells; genetically encoded sensors have revolutionized the study of this type of phenomenon, since they offer a convenient tool to measure bioenergetic changes in live cells.