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Team deciphers how myotonic dystrophy generates lethal heart dysfunctions

February 28, 2020

Roughly 80% of people with myotonic dystrophy – a common form of muscular dystrophy – experience dangerous heart ailments, and heart rhythm defects are the second-leading cause of death in those with the condition. In a new study, researchers traced the molecular events that lead to heart abnormalities in myotonic dystrophy and recreated the disease in a mouse model.

They report their findings in the journal Developmental Cell.


February 28, 2020


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Study identifies key player in heart enlargement

June 27, 2017

The heart is a dynamic muscle that grows and shrinks in response to stressors such as exercise and disease. The secret to its malleability lies in individual cells, which get bigger or smaller depending on the heart’s needs. A new study of mouse hearts reveals a previously unknown mechanism by which heart cells control their size by ramping up or stopping the production of a key factor called PABPC1.


June 27, 2017


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Scientists uncover mechanism that propels liver dev. after birth

November 5, 2015

Any expectant mother will tell you that she wants her baby's organs to develop properly in the womb.

What she may not realize, however, is that a child's internal organs continue to develop for months and years after birth. This critical period is full of cellular changes that transform the organization and function of most tissues. But the exact mechanisms underlying postnatal organ maturation are still a mystery.


November 5, 2015


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