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Meng Zhang

Genome-editing tool TALEN outperforms CRISPR-Cas9 in tightly packed DNA

January 28, 2021

Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN. Their experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome, called heterochromatin, that are densely packed. Fragile X syndrome, sickle cell anemia, beta-thalassemia and other diseases are the result of genetic defects in the heterochromatin.


January 28, 2021


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