Drugs

The spread of drug-resistant microbes has become a global health concern that threatens our ability to treat infections. The widespread use of antimicrobials in livestock, such as swine farms, exacerbates this problem. Therefore, we need surveillance systems to monitor these microbes to support the public health authorities. To this end, researchers have tracked the antimicrobial resistance of Escherichia coli isolated from swine.

Artificial intelligence, “building-block” chemistry and a molecule-making machine teamed up to find the best general reaction conditions for synthesizing chemicals important to biomedical and materials research – a finding that could speed innovation and drug discovery as well as make complex chemistry automated and accessible.

In honor of the IGB's anniversary, we're revisiting some of the history of our institute over the past 15 years with a series of articles highlighting IGB people, projects, and research.

Oxidants found within living organisms are byproducts of metabolism and are essential to wound-healing and immunity. However, when their concentrations become too high, inflammation and tissue damage can occur. University of Illinois engineers have developed and tested a new drug-delivery system that senses high oxidant levels and responds by administering just the right amount of antioxidant to restore this delicate balance.

The findings are published in the journal Small.

Bacteria are master engineers of small, biologically useful molecules. A new study in Nature Communications (DOI: 10.1038/s41467-018-06083-7) has revealed one of the tricks of this microbial trade: synthesizing and then later inserting a nitrogen-nitrogen bond, like a prefabricated part, into a larger molecule.

Illinois researchers develop a database that will guide and streamline the search for naturally produced antibiotics