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Breast Cancer

New approach eradicates breast cancer in mice

July 21, 2021

A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.

Led by scientists at the University of Illinois Urbana-Champaign, the research team reports the findings in the journal Science Translational Medicine.


July 21, 2021


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Cholesterol metabolite induces production of cancer-promoting vesicles

June 9, 2021

Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.


June 9, 2021


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Nelson awarded $4.5M to study prevention, treatment of breast cancer

October 30, 2020

Professor of Molecular and Integrative Physiology Erik Nelson (ACPP) has won a $4.5M Era of Hope Scholar Award from the United States Department of Defense (DoD) Breast Cancer Research Program (BCRP). This prestigious award supports individuals early in their careers who have demonstrated significant potential to effect meaningful change in breast cancer research. Recipients of the Era of Hope Scholar Award are leaders and visionaries in their respective field who go beyond conventional thinking to change the current landscape of breast cancer research and therapy.


October 30, 2020


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Woese Undergraduate Scholars set for a summer of science

July 16, 2019

Two of the most basic motivations that drive scientific research—exploration of the unknown and the desire to solve a pressing problem—are represented by this year’s Carl R. Woese undergraduate research scholars. Allison Narlock will spend her summer investigating the mechanics of archaeal cell division; Monika Ziogaite will be working to identify genetic variants that contribute to the metastatic potential of breast cancers.


July 16, 2019


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Drugs reprogram genes in breast tumors to prevent endocrine resistance

April 23, 2019

Treating breast tumors with two cancer drugs simultaneously may prevent endocrine resistance by attacking the disease along two separate gene pathways, scientists at the University of Illinois found in a new study.

The two drugs used in the study, selinexor and 4-OHT, caused the cancer cells to die and tumors to regress for prolonged periods, said food science and human nutrition professor Zeynep Madak-Erdogan (ONC-PM), the principal investigator on the study.


April 23, 2019


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Fatty acids rewire cells to promote obesity-related breast cancer

March 13, 2019

Scientists at the University of Illinois have found that free fatty acids in the blood appear to boost proliferation and growth of breast cancer cells. The finding could help explain obese women’s elevated risk of developing breast cancer after menopause.


March 13, 2019


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Cholesterol byproduct hijacks immune cells, lets breast cancer spread

October 13, 2017

High cholesterol levels have been associated with breast cancer spreading to other sites in the body, but doctors and researchers don't know the cause for the link. A new study by University of Illinois researchers found that the culprit is a byproduct of cholesterol metabolism that acts on specific immune cells so that they facilitate the cancer's spread instead of stopping it.


October 13, 2017


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