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Carl R. Woese Institute for Genomic Biology

Where Science Meets Society

Larger sample sizes needed to increase reproducibility in neuroscience studies

Small sample sizes in studies using functional MRI to investigate brain connectivity and function are common in neuroscience, despite years of warnings that such studies likely lack sufficient statistical power. A new analysis reveals that task-based fMRI experiments involving typical sample sizes of about 30 participants are only modestly replicable. This means that independent efforts to repeat the experiments are as likely to challenge as to confirm the original results.

Theory: Flexibility is at the heart of human intelligence

Centuries of study have yielded many theories about how the brain gives rise to human intelligence. Some neuroscientists think intelligence springs from a single region or neural network. Others argue that metabolism or the efficiency with which brain cells make use of essential resources are key.

A new theory, published in the journal Trends in Cognitive Sciences, makes the case that the brain’s dynamic properties – how it is wired but also how that wiring shifts in response to changing intellectual demands – are the best predictors of intelligence in the human brain.

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