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Carl R. Woese Institute for Genomic Biology

Where Science Meets Society

Jumping genes shed light on how advanced life may have emerged

A previously unappreciated interaction in the genome turns out to have possibly been one of the driving forces in the emergence of advanced life, billions of years ago.

This discovery began with a curiosity for retrotransposons, known as “jumping genes,” which are DNA sequences that copy and paste themselves within the genome, multiplying rapidly. Nearly half of the human genome is made up of retrotransposons, but bacteria hardly have them at all.

"Jumping genes": Real-time transposon activity in living cells

“Jumping genes” are ubiquitous. Every domain of life hosts these sequences of DNA that can “jump” from one position to another along a chromosome; in fact, nearly half the human genome is made up of jumping genes. Depending on their specific excision and insertion points, jumping genes can interrupt or trigger gene expression, driving genetic mutation and contributing to cell diversification.

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