Skip to main content

Illinois IGB

Pablo Perez-Pinera

New CRISPR base-editing technology slows ALS progression in mice

February 24, 2020

With a new CRISPR gene-editing methodology, scientists from the University of Illinois at Urbana-Champaign inactivated one of the genes responsible for an inherited form of amyotrophic lateral sclerosis – a debilitating and fatal neurological disease for which there is no cure. The novel treatment slowed disease progression, improved muscle function and extended lifespan in mice with an aggressive form of ALS.


February 24, 2020


Related Articles

Illinois researchers are first to count growth factors in single cells

February 25, 2019

Whether healthy or diseased, human cells exhibit behaviors and processes that are largely dictated by growth factor molecules, which bind to receptors on the cells. For example, growth factors tell the cells to divide, move, and when to die—a process known as apoptosis.


February 25, 2019


Related Articles

New CRISPR technique skips over portions of genes that can cause disease

August 16, 2018

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.


August 16, 2018


Related Articles

Subscribe to Pablo Perez-Pinera