CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study led by University of Illinois Urbana-Champaign researchers suggests. The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now. 

The results of a recent canine cancer study by Tim Fan (ACPP/CGD), a professor of veterinary clinical medicine, and former Illinois faculty member Dane Wittrup may have positive implications for future approaches to cancer immunotherapy.

A method known as CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient’s own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new study, researchers report that they have dramatically broadened the potential targets of this approach – their engineered T-cells attack a variety of solid-tumor cancer cells from humans and mice.