Brendan Harley

Bone injuries in the face and skull—known as craniomaxillofacial defects—can be caused by sports injuries, vehicle accidents, or battlefield injuries. Repairing such defects is complicated because different types of cells need to interact with each other. In a new study, researchers are investigating the types of material used in reconstruction to see which one works best.

A new research project led by the University of Illinois Urbana-Champaign aims to develop biomaterials that are strong, malleable, and support stem cell growth to transform skull reconstruction surgeries with a $2.4 million grant over five years from the National Institute of Dental and Craniofacial Research, a branch of the U.S. National Institutes of Health. 

Several Cancer Center at Illinois (CCIL) and IGB members are joining forces with scientists from the Mayo Clinic and Georgetown University on an expansive project targeting improved treatment for glioblastoma (GBM), the most aggressive form of brain cancer. The team, led by Brendan Harley (RBTE leader/EIRH), professor of chemical and biomolecular engineering, recently received a $3M grant from the National Cancer Institute (NCI) for their research which will unite the cell biology, bioengineering, and chemistry behind cancer drug development.

Neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis affect millions of people worldwide and yet, there exist no known cures. Multiple sclerosis, a disease that causes deterioration of the nerves due to miscommunication between the brain and body, was of particular interest to Illinois alumnus Scott Fisher. As an alumnus, Fisher had a desire to give back to the university but to also honor his late wife Bonita J. Fisher, who was diagnosed with multiple sclerosis.

The American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Dr. Brendan Harley, Professor of Chemical and Biomolecular Engineering, to its College of Fellows.

A team of researchers from the IGB’s Regenerative Biology and Tissue Engineering (RBTE) theme was awarded a NSF grant that will provide funding for a new 3D-bioprinting instrument.

The Major Research Instrumentation grant will fund the purchase of an EnvisionTEC 3D-Bioplotter, a bioprinting system that is essentially a 3D printer for tissues.

Researchers Develop New Approach for Studying Deadly Brain Cancer

Human glioblastoma multiforme, one of the most common, aggressive and deadly forms of brain cancer, is notoriously difficult to study. Scientists have traditionally studied cancer cells in petri dishes, which have none of the properties of the brain tissues in which these cancers grow, or in expensive animal models.