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Carl R. Woese Institute for Genomic Biology

Where Science Meets Society


Invasion’s forefront
Multiphoton Confocal Microscope Zeiss 710 with Mai Tai eHP Ti: sapphire laser and Imaris

Image provided by John Paul Eichorst, Robert Clegg, Glenn Fried, and Yingxiao Wang, Robert Clegg Lab 
Research funded by National Institutes of Health

MT1-MMP is a protein found on the membrane of metastatic cancer cells. By collecting a series of thin images and building them into the 3-dimensional images like this one, scientists observed previously unknown activation patterns of MT1-MMP. With further improvements in imaging systems, researchers aim to eventually be able to monitor in 3-D the activity of MT1-MMP as a live cancer cell travels through the body.