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New compounds block master regulator of cancer growth, metastasis

January 3, 2020

Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer.

The researchers report their findings in the journal NPJ Breast Cancer.


January 3, 2020


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Molecular probe illuminates elusive cancer stem cells in live mice

August 2, 2018

After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that’s more aggressive and resistant to treatment. University of Illinois researchers have developed a molecular probe that seeks out these elusive cells and lights them up so they can be identified, tracked and studied not only in cell cultures, but in their native environment: the body.


August 2, 2018


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Products of omega-3 fatty acid metabolism may have anticancer effects

July 16, 2018

A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer’s growth and spread, University of Illinois researchers report in a new study in mice. The molecules, called endocannabinoids, are made naturally by the body and have similar properties to cannabinoids found in marijuana – but without the psychotropic effects.


July 16, 2018


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New NIH-funded research aims to improve prostate cancer outcomes

March 30, 2018

University of Illinois at Urbana-Champaign researchers recently received a $1.8 million grant from the National Institutes of Health (NIH) to develop a new assay technology that could determine the effectiveness of cancer drug treatments and aid in disease prognosis. Led by Illinois Bioengineering Assistant Professor Andrew Smith, the team is focusing on detecting nucleic acid-based biomarkers in a single drop of a cancer patient's blood.


March 30, 2018


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Cancer drug starts clinical trials in human brain-cancer patients

November 27, 2017

A drug that spurs cancer cells to self-destruct has been cleared for use in a clinical trial of patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain. This phase Ib trial will determine if the experimental drug PAC-1 can be used safely in combination with a standard brain-cancer chemotherapy drug, temozolomide.


November 27, 2017


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New Research Theme to Develop Precision Medicine Tools

August 1, 2016

Researchers at Mayo Clinic, the Carl R. Woese Institute for Genomic Biology (IGB) and from the University of Illinois Macro and Nanotechnology Laboratory (MNTL) are collaborating in a new research theme focusing on using micro RNAs and nanotechnology to develop technologies to characterize tumors and monitor how they grow.


August 1, 2016


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Scientists test nanoparticle drug delivery in dogs with osteosarcoma

July 25, 2016

At the University of Illinois, an engineer teamed up with a veterinarian to test a bone cancer drug delivery system in animals bigger than the standard animal model, the mouse. They chose dogs – mammals closer in size and biology to humans – with naturally occurring bone cancers, which also are a lot like human bone tumors.


July 25, 2016


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Shape of tumor may affect whether cells can metastasize

April 28, 2016

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new University of Illinois study.


April 28, 2016


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