The Carl R. Woese Institute for Genomic Biology has hosted numerous research centers over the years, fostering collaboration between researchers at the IGB and external partners, including those of academic, governmental, and industrial nature. The IGB’s centers often work together with multiple institutions and companies, producing interdisciplinary research that is then translated into real-world solutions. Here, we discuss the centers both past and current that the IGB has hosted over the last 15 years.