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Nikon Ti Eclipse Microscope

Surbhi Jain

Huimin Zhao Laboratory

Funded by the NIH

Genome editing holds immense promise in revolutionizing all aspects of medicine and many other industries. By understanding how gene editing proteins behave inside the cell at the single molecule level, researchers can gain insights into designing highly specific technologies.

CRISPR has been deservedly recognized as an efficient way to edit DNA, but scientists have other strategies to choose from. TALE molecular pathways are more accurate than CRISPR in their identification of DNA sites to be edited. This image evokes the precise pathways taken by the TALE molecules along strands of DNA in living cells.