Image provided by Xinshuai Zhang, John Gerlt Lab
Research funded by the National Institutes of Health
This series of plots represents the change in structure over time of an enzyme interacting with its substrate. Enzymes are proteins that catalyze chemical processes by interacting with the reactants. Researchers involved in drug design need information about reaction mechanisms, and how enzymes support them. Examining the changing structure of the enzyme-reactant interaction over the course of the reaction reveals important information about these mechanisms.